ScienceDaily: Breast Cancer News
Fri, 05 Dec 2008 04:05:01 EST

Protein That Determines Cell Polarity Prevents Breast Cancer, Study Suggests
A team of scientists has found that a protein called Scribble, originally discovered as a cell-shape regulator in fruit flies and worms, is an important regulator of breast cancer. They report that Scribble normally directs breast epithelial cells to form the structures that give breast tissue its shape and thereby resist cancer formation. When Scribble stops functioning, the tissue loses its shape and cancers ensue.
Thu, 04 Dec 2008 17:00:00 EST

Angled Gantry Technique Reduced Breast Radiation Exposure By 50 Percent
A novel angled gantry approach to coronary CT angiography reduced radiation exposure to the breast by more than 50 percent, according to researchers.
Thu, 04 Dec 2008 00:00:00 EST

Curbing Hormones' Effects In Obese Patients Could Aid Against Breast Cancer
Results from cell culture studies suggest a class of anticancer compounds called EGFR inhibitors, largely written off for breast cancers, could be effective in obese patients. The hormones leptin and IGF-1 synergistically stimulate migration and invasion in breast cancer cells. EGFR inhibitors block this stimulation.
Wed, 03 Dec 2008 20:00:00 EST

Drop In Cancer Deaths Tied Primarily To Gains In Behavior And Screening
Behavior change and improvements in screening have contributed equally and substantially to the 13 percent decline in cancer mortality rates, according to new research. Cancer treatment after diagnosis has also contributed to the decline, although this is less of a factor than behavioral changes and screening.
Wed, 03 Dec 2008 08:00:00 EST

Novel Basis Identified For Tamoxifen Failure
Tamoxifen may worsen breast cancer in a small subset of patients. New research suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-estrogen drugs such as tamoxifen may promote more harmful cancer cell behavior.
Wed, 03 Dec 2008 00:00:00 EST

Breast Cancer News From Medical News Today
Fri, 05 Dec 2008 11:01:24 +0100

Novel Basis Identified For Tamoxifen Failure
Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal Breast Cancer Research suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour. A team of researchers co-ordinated by Dr.
Thu, 04 Dec 2008 05:00:00 PST

Breast Radiation Exposure Reduced By 50 Percent Using Angled Gantry Technique
A novel angled gantry approach to coronary CT angiography reduced radiation exposure to the breast by more than 50%, according to Thomas Jefferson University researchers. Ethan Halpern, M.D., associate professor of Radiology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, presented the research at the 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America.
Thu, 04 Dec 2008 04:00:00 PST

New Breast Imaging Technology Targets Hard To Detect Cancers
Breast-specific gamma imaging (BSGI) is effective in the detection of cancers not found on mammograms or by clinical exam, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA). "BSGI can identify the most difficult to detect breast cancer-invasive lobular carcinoma," said lead author Rachel F. Brem, M.D.
Thu, 04 Dec 2008 00:00:00 PST

Molecular Breast Imaging Identifies Occult Cancer
Breast-Specific Gamma Imaging (BSGI) is shown to be an effective method of identifying mammographically and clinically occult (hidden) breast cancer. BSGI is a molecular breast imaging technique that can see lesions independent of tissue density and discover very early stage cancers.
Thu, 04 Dec 2008 00:00:00 PST

HER2 Levels May Aid In Treatment Selection For Metastatic Breast Cancer
Findings published in the December 1, 2008, issue of Clinical Cancer Research , a journal of the American Association for Cancer Research, show lapatinib benefits women with HER2-positive breast cancer, while women with HER2-negative breast cancer or those who express EGRF alone derive no incremental benefit.
Wed, 03 Dec 2008 06:00:00 PST

Behavior And Screening Have Biggest Impact On Drop In Cancer Deaths
Improvements in behavior and screening have contributed greatly to the 13 percent decline in cancer mortality since 1990, with better cancer treatments playing a supporting role, according to new research from David Cutler of Harvard University. While not the first to report a long-term decline in cancer mortality, Cutler's is the first study to examine the reasons for this decline.
Wed, 03 Dec 2008 05:00:00 PST

Studies Evaluate Breast Cancer Outcomes In Older Patients, Women With Breast Augmentations
The following summarizes news coverage of two recent studies on breast cancer treatment.~ Older Patients: One in five women ages 65 and older delayed or did not complete their full radiation regimen after breast-conserving surgery, leading to an increased risk of death or recurrence, according to a study published online Monday in Cancer, the
Wed, 03 Dec 2008 02:00:00 PST

Linda Creed Announces Volunteer Recognition Awards
Linda Creed, an affiliate of Public Health Management Corporation (PHMC), will hold their annual Volunteer Recognition Awards this Saturday, December 6 at 11 a.m. The awards are given in recognition of individuals, corporations, and health organizations that have made a significant difference in the ability to provide access to basic breast health in the region. The Linda Creed Volunteer of the Year Award will go to Gerard Olson, Ph.D., of Villanova University. "Dr.
Wed, 03 Dec 2008 01:00:00 PST

New Mammography Technology Effective In Detecting Breast Cancer
A study has found that positron emission mammography (PEM), a new technique for imaging the breast, is not affected by either breast density or a woman's hormonal status, two factors that limit the effectiveness of standard mammography and MRI at detecting cancer. Results will be presented today at the annual meeting of the Radiological Society of North America (RSNA).
Wed, 03 Dec 2008 00:00:00 PST

Curbing Hormones' Effects In Obese Patients Could Aid Against Breast Cancer
Once-promising drugs that were abandoned in the fight against breast cancer still could be effective in obese patients, new research suggests. In laboratory tests, hormones produced by fat cells stimulate breast cancer cells to migrate and invade surrounding tissues, scientists at Emory University School of Medicine found. A class of drugs called epithelial growth factor receptor (EGFR) inhibitors could block the stimulatory effects of the hormones.
Tue, 02 Dec 2008 06:00:00 PST